| Top 2016 Illinois Presidential Republican Counties by Percentage |
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| Rank | Region | Votes | % of Votes |
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| 1 | Edwards County | 2,777 | 83.8 | | 2 | Wayne County | 6,963 | 84.3 | | 3 | Clay County | 5,009 | 79.8 | | 4 | Pope County | 1,678 | 78.7 | | 5 | Effingham County | 13,613 | 78.1 | | 6 | Jasper County | 3,973 | 77.8 | | 7 | Johnson County | 4,644 | 77.2 | 
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